The sclera, the prion, and the ophthalmologist.
نویسندگان
چکیده
Prions have emerged in the past 5 years as serious transmissible infective agents. Ocular tissue transplantation has come under scrutiny after potential infected tissue was transplanted into healthy patients. In this review we examine the evidence for the risk of transmission of prions after scleral transplantation and explore alternative materials that may be used in ocular surgery.
منابع مشابه
Introducing critical residues in the human prion protein and its Asp 178 Asn mutant by molecular dynamics simulation
The molecular dynamics (MD) simulation method is used to assess structural details for humanprion protein (hereafter PrPN) and its Asp178 Asn mutant (hereafter PrPm) which causes fatalfamilial insomnia disease. The results reveal that the flexibility and instability increase in PrPmcould be related to specific amino acids exposed to the solvent. Solvation free energy of PrPm is 20kjmot1nni2 mor...
متن کاملA Study on The Effect of Temperature on Human Prion Protein Structure through Molecular Dynamic Simulation
Background & Aims: The normal form of the prion protein is called PrPC and its infectious form is called PrPSc. This protein functions like a crystallized core for the transformation of PrPc into an abnormal PrPSc. The aim of the present study was to investigate the effect of temperature on human prion protein structure through molecular dynamic simulation. Methods: In this research, the GROMAC...
متن کاملارزیابی و مقایسه نتایج عمل جراحی ناخنک اولیه به دو روش Rotational Flap و Bare Sclera
The objective of this study was the comparison of Bare Sclera and Rotational Flap methods in primary pterygium surgery. This study was retrospective Cohort and studied population were 80 patients (40 patients in each group) with primary pterygium in stage II and III operated in Hamadan Emam Khomeini hospital , during 2001-2003. All of the patients followed up...
متن کاملPolymorphism of Prion Protein Gene (PRNP) in Iranian Holstein and Two Local Cattle Populations (Golpayegani and Sistani) of Iran
Bovine spongiform encephalopathy (BSE) is a fatal infectious neurodegenerative disease in cattle, characterized by the accumulation of an abnormal, proteaseresistant prion protein (PrPSc) in the brain. BSE is similar to scrapie in sheep and goats and Creuzfeldt-Jakob disease in humans. Susceptibility in cattle hasbeen shown to be under the influence of two polymorphic locations, which are...
متن کاملReasons for Participation of Ophthalmologist in Continuing Medical Education
Purpose: Today, Continues Medical Education (CME) is considered as one of the methods to improve knowledge and clinical performance of physicians. In this regard, all physicians will become familiar with new and more effective therapies and are encouraged to follow them. The present qualitative study aims at explaining the reasons for the participation of Iranian ophthalmologists in continuing ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The British journal of ophthalmology
دوره 86 5 شماره
صفحات -
تاریخ انتشار 2002